Which prescription brands could go nonprescription?
We grade each brand from A+ to F on how feasible it would be to sell it without a prescription under ACNU. ACNU is the FDA rule that lets a drug go nonprescription if buyers first complete an added step, such as a screening questionnaire. Each condition a brand treats gets its own grade too.
How these grades are madeBrands graded
200
Each has a drug grade and a grade for every condition it treats.
Graded A or B
82
An A or B means people could likely use the drug safely without a prescriber.
Both grades A or B
47
The drug and at least one condition it treats are both graded A or B.
These grades are our estimates, not FDA decisions. As of August 13, 2026, FDA had not approved any drug under ACNU. The data was last refreshed in October 2026.
Browse by grade
Every brand gets two grades.
- Both grades A or B: 47 brands
- Selected box
How to read this: each letter includes its plus and minus grades, so A means A+, A or A-. A brand is counted once for each condition it treats, so a brand with three graded conditions is counted three times.
Selected box
Drug grade A, condition grade A
3 results
Browse by therapeutic area
Therapeutic areas, ranked by A and B grades.
Not ranked: Allergy (4) and Rare and genetic (1). An area needs at least 6 graded brands to be ranked.
Selected area · ranked 1 of 14
Kidney and urology
8 of 12 brands are graded A or B.
Top-graded brands
Where this area scores worst
Average score across this area’s brands for each scorecard item, from 1 to 10. Higher means more risk. The highest is highlighted.
Safety and Risk Profile
- Severity of Side Effects
- 5.5
- Therapeutic Window & Overdose Potential
- 3.2
- Risk of Misuse
- 3.3
- Drug-Drug Interactions
- 5.2
- Special Considerations (highest)
- 6.3
Usability Difficulty
- Dosing Complexity & Route of Administration
- 2.8
- Monitoring Requirements
- 6.2
- Adherence Difficulty
- 2.7
- Potential for Tolerance
- 2.0
Brand profiles
Every brand has a profile that explains its grade.
Vizz
Lenz Therapeutics Inc
Treats
- Presbyopia (condition grade A-)
Highest-risk score
- Monitoring Requirements5 out of 10
Flumist, Flumist Quad
MedImmune, LLC
Treats
- Influenza (condition grade B)
Highest-risk score
- Special Considerations5 out of 10
Repatha
Amgen Inc
Treats
- High Cholesterol (condition grade B-)
Highest-risk score
- Dosing Complexity & Route of Administration5 out of 10
Zofran
Glaxosmithkline
Treats
- Nausea (condition grade B-)
Highest-risk score
- Special Considerations5 out of 10
How we grade
Grades are based on FDA data.
Scores are based on public sources you can check: the drug’s FDA label, FDA’s adverse event reports, and its DEA schedule. Two rules can override the scores. A drug with a boxed warning cannot grade higher than C+. A drug on DEA Schedule II, III or IV gets an F.
Read the full methodologyThe drug grade
Could people use this drug safely without a prescriber?
Nine scores from 1 to 10, where lower is better. Five cover safety: side effects, overdose, misuse, interactions, and risk for groups such as children or pregnant women. Four cover use: dosing, monitoring, adherence, and loss of effect over time.
The condition grade
How strong is the case for a nonprescription option?
Nine scores in three groups: how large the unmet need is, how heavy the burden of the disease is, and how well people can tell they have the condition without a clinician.
Connect With Us
Talk to us about your brand’s grade.
Whether the opportunity begins with visibility or nonprescription access, we’ll help you find the clearest next move across Search, AI and ACNU.
contact@idea-evolver.com